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Retained blood syndrome (RBS) results from the ineffective evacuation of blood and fluid from a surgical or traumatic wound after surgery. This can happen after nearly any operation or major trauma, but especially operations like heart surgery, thoracic surgery, trauma surgery, general surgery, orthopedic surgery, neurosurgery, pelvic surgery or plastic surgery. In nearly all of these specialties, surgical drains are needed to removed blood and fluid from the surgical wounds in the early phase of recovery. RBS can develop when these drains fail to perform the required task that is to drain blood, fluid, and air from the surgical wound. Although RBS can occur after any procedure that requires a drainage catheter, RBS is probably best recognized after cardiac surgery, where chest tubes are used to drain blood from around the heart and lungs in the early hours after surgery. If the evacuation of blood is incomplete, RBS can occur. Clinically, RBS can be recognized acutely or subacutely. When it presents acutely, it is usually fresh thrombus around the heart or lungs presenting as tamponade or hemothorax. When it presents subacutely, it results in bloody pleural or pericardial effusions.〔Light, R.W., Rogers, J.T., Moyers, J.P., et al. Prevalence and Clinical Course of Pleural Effusions at 30 Days after Coronary Artery and Cardiac Surgery. Am J Respir Crit Care Med. 2002;166:1567-1571. doi: 10.1164/rccm.200203-184OC.〕〔Christensen, M.C., Dziewior, F., Kempel, A., and von Heymann, C. 2012. Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth 26:46-51.〕〔Light, R.W. 2001. Pleural effusions following cardiac injury and coronary artery bypass graft surgery. Semin Respir Crit Care Med 22:657-664.〕〔Light, R.W. 2002. Pleural effusions after coronary artery bypass graft surgery. Curr Opin Pulm Med 8:308-311.〕〔Light, R.W., Rogers, J.T., Cheng, D., and Rodriguez, R.M. 1999. Large pleural effusions occurring after coronary artery bypass grafting. Cardiovascular Surgery Associates, PC. Ann Intern Med 130:891-896.〕〔Ikaheimo, M.J., Huikuri, H.V., Airaksinen, K.E., Korhonen, U.R., Linnaluoto, M.K., Tarkka, M.R., and Takkunen, J.T. 1988. Pericardial effusion after cardiac surgery: incidence, relation to the type of surgery, antithrombotic therapy, and early coronary bypass graft patency. Am Heart J 116:97-102〕 Once RBS occurs, subsequent procedures may be needed to remedy it. In an analysis of the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (NIS) data from 2010, RBS could be demonstrated in 17% of patients. In this analysis, mortality was doubled from 3% to 6%, length of stay was increased by 5 days, and average costs were 55% higher.〔Analysis performed by Fletcher Spaght, Inc. using Heart Surgery ICD-9 codes to extract data from the 2010 Nationwide Inpatient Sample (NIS) from the DHHS Agency for Healthcare Research and Quality (AHRQ) and the Healthcare Cost and Utilization Project (HCUP).〕 Patients with RBS, therefore, appear to be at increased at risk for complications and costs. Recently it has become better understood that the postoperative obstruction of conventional chest tubes with blood and other fibrinous material in the setting of postoperative bleeding is central to the root cause of RBS.〔Clark, G., Licker, M., Bertin, D., and Spiliopoulos, A. 2007. Small size new silastic drains: life-threatening hypovolemic shock after thoracic surgery associated with a non-functioning chest tube. Eur J Cardiothorac Surg 31:566-568.〕 When blood encounters the surfaces of chest tubes, the coagulation cascade is initiated, which often lead to partial or complete chest tube clogging with clot. In a recent study of postoperative cardiac surgery patients at the Cleveland Clinic, 36% of patients were found to have evidence of chest tube obstruction.〔Christensen, M.C., Dziewior, F., Kempel, A., and von Heymann, C. 2012. Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery. J Cardiothorac Vasc Anesth 26:46-51.〕〔Karimov, J.H., Gillinov, A.M., Schenck, L., et al. Incidence of chest tube clogging after cardiac surgery: a single-centre prospective observational study. Eur J Cardiothorac Surg. 2013;44(6):1029-1036. doi:10.1093/ejcts/ezt140〕 If chest tube obstruction occurs when a patient is still bleeding after heart surgery, RBS ensues. A growing body of literature suggests links between retained blood and the development of postoperative atrial fibrillation (POAF) and other complications. Postoperative atrial fibrillation is one of the most common complications after heart surgery, occurring in 20% to 60% of patients, and is a leading cause of hospital readmissions. Patients with occluded chest tubes have been shown to have a higher rate of POAF. Although the precise mechanism that explains why patients with RBS have higher POAF is unclear, inflammation from clot in the pericardium may be contributory. Active clearance of chest tubes with the (PleuraFlow ) Active Clearance Technology System can reduce RBS. In one study, a multidisciplinary team developed a simple protocol to institute active clearance to preventatively clear chest tubes of clot during the first 24 hours after heart surgery. In matched patients, 19.9% of patients had interventions for RBS (baseline). After the implementation of active clearance with PleuraFlow (treatment group), the percent of patients with interventions for RBS was reduced to 11.3%, representing a 43% reduction in RBS (P = .0087). These patients had a 33% reduced incidence of postoperative atrial fibrillation (POAF) with PleuraFlow. These findings underscore the importance of maintaining chest tube patency in the early hours after cardiac surgery. The costs of RBS are high. In one analysis of over 313,000 adult cardiac surgery patients from the 2010 Nationwide Inpatient Sample (NIS), from the DHHS Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilization Project (HCUP), it was found that the incremental increase in costs for RBS is as high as $28,814 per patient in the US.〔2010 Nationwide Inpatient Sample (NIS), from the DHHS Agency for Healthcare Research and Quality (AHRQ) Healthcare Cost and Utilization Project (HCUP). Data extracted using ICD-9 codes from over 313,000 US adult heart surgery patients. Analysis performed by Fletcher Spaght, Inc.〕 This suggests that there can be considerable finacialfinancial savings for hospitals by reducing even a small percentage of patients with RBS by preventing chest tube clogging after heart surgery. The result of ineffective evacuation of blood and fluid from a surgical or traumatic wound after surgery has also been reported in the literature under other names, including Retained Blood Complications (RBC), Retained Blood Complex (RBC) and Failure to Drain. ==References== 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Retained Blood Syndrome」の詳細全文を読む スポンサード リンク
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